Genetic Testing for Lynch Syndrome and Inherited Intestinal Polyposis Syndromes
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چکیده
When Policy Topic is covered Genetic testing for APC gene mutations may be considered medically necessary in the following patients: At-risk relatives (see Considerations) of patients with FAP and/or a known APC mutation. Patients with a differential diagnosis of attenuated FAP vs. MYH-associated polyposis vs. Lynch syndrome. Whether testing begins with APC mutations or screening for MMR mutations depends upon clinical presentation.
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